| 货号 | 10139-500ug |
| 描述 | 2-Arachidonoyl glycerol (2-AG; Item No. 62160) has been isolated from porcine brain, and has been characterized as the natural endocannabinoid ligand for the central cannabinoid receptor.1,2 Incubation of 2-AG with cyclooxygenase-2 and specific prostaglandin H2(PGH2) isomerases in cell cultures and isolated enzyme preparations results in PG glyceryl ester formation.3 The biosynthesis of PGH, PGD, PGE, PGF, and thromboxane A-2-glyceryl ester compounds have all been documented. The 2-glyceryl ester moiety equilibrates rapidly (within minutes) with the more stable 1-glyceryl ester, producing a 10:90 2:1-glyceryl ester mixture in typical aqueous media. While the stability and metabolism of PGF2α-1-glyceryl ester has been investigated, little is known about its intrinsic biological activity.4 |
| 别名 | PGF2α-1-glyceryl ester; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Sugiura, T.,Kodaka, T.,Kondo, S., et al. 2-Arachidonoylglycerol, a putative endogenous cannabinoid receptor ligand, induces rapid, transient elevation of intracellular free Ca2+ in neuroblastoma X glioma hybrid NG108-15 cells. Biochemical and Biophysical Research Communications 229, 58-64 (1996). 2.Sugiura, T.,Kodaka, T.,Kondo, S., et al. Is the cannabinoid CB1 receptor a 2-arachidonoylglycerol receptor? Structural requirements for triggering a Ca2+ transient in NG108-15 cells. Journal of Biochemistry 122, 890-895 (1997). 3.Kozak, K.R.,Crews, B.C.,Morrow, J.D., et al. Metabolism of the endocannabinoids, 2-arachidonylgycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides. The Journal of Biological Chemisty 277(47), 44877-44885 (2002). 4.Kozak, K.R.,Crews, B.C.,Ray, J.L., et al. Metabolism of prostaglandin glycerol esters and prostaglandin ethanolamides in vitro and in vivo. The Journal of Biological Chemisty 276(40), 36993-36998 (2001). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% (as a 9:1 mixture of the 2- and 1-glyceryl esters) |
| 计算分子量 | 428.6 |
| 分子式 | C23H40O7 |
| CAS号 | 43042-79-1 |
| 稳定性 | ≥ 1 year |
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