N-Oleoyl Dopamine
货号：
10115-5mg 基本售价：
490.0 元 规格：
5 mg
产品信息
概述| 货号 | 10115-5mg |
| 描述 | N-Oleoyl dopamine (ODA) is a selective, endogenous vanilloid receptor 1 (VR1) agonist isolated from bovine brain.1 Structurally, it is the amide of oleic acid and dopamine and is therefore a “hybrid” analog which incorporates components of both the anandamide-like and dopamine neurotransmitter pathways. ODA binds to the human recombinant VR1 with a Ki of 36 nM making it equipotent to capsaicin and slightly more potent than N-arachidonoyl dopamine in this assay.1 It causes hyperalgesia and nocifensive behavior that is blocked by the VR1 antagonist iodo-resiniferatoxin. ODA is selective for VR1 based on observations that it has weak affinity for the rat CB1 receptor (Ki of 1.6 µM) and is a very weak inhibitor of FAAH. ODA is also a potent inhibitor of 5-lipoxygenase from rat basophilic leukemia-1 (RBL-1) cells, with a IC50 of 7.5 nM.2,3 |
| 别名 | ODA; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Chu, C.J.,Huang, S.M.,De Petrocellis, L., et al. N-oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia. The Journal of Biological Chemisty 278(16), 13633-13639 (2003).
2.Tseng, C.F.,Iwakami, S.,Mikajiri, A., et al. Inhibition of in vitro prostaglandin and leukotriene biosyntheses by cinnamoyl-β-phenethylamine and N-acyldopamine derivatives. Chemical & Pharmaceutical Bulletin 40(2), 396-400 (1992).
3.Iwakami, S.,Shibuya, M.,Tseng, C.F., et al. Inhibition of arachidonate 5-lipoxygenase by phenolic compounds. Chemical & Pharmaceutical Bulletin 34, 3960-3963 (1986).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 417.6 |
| 分子式 | C26H43NO3 |
| CAS号 | 105955-11-1 |
| 稳定性 | ≥ 1 year |
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