| 货号 | 10054-1mg |
| 描述 | The liver X receptors, LXRα and LXRβ, are nuclear receptors that act as ligand-dependent transcription factors.1 They modulate cholesterol, fatty acids, and glucose homeostasis. GW 3965 is an orally-active agonist of LXRα and LXRβ, activating the human isoforms with EC50 values of 190 and 30 nM, respectively.2 It alters LXR-regulated gene expression in mice and rats, affecting pathways related to glucose and lipid metabolism.2,3,4 GW 3965 also affects inflammation and pressor responses through LXRα and LXRβ.5,6,7 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Gabbi, C.,Warner, M. and Gustafsson, J.Ä. Action mechanisms of liver X receptors. Biochemical and Biophysical Research Communications 446(3), 647-650 (2014). 2.Collins, J.L.,Fivush, A.M.,Watson, M.A., et al. Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines. Journal of Medicinal Chemistry 45, 1963-1966 (2002). 3.Joseph, S.B.,McKilligin, E.,Pei, L., et al. Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Proceedings of the National Academy of Sciences of the United States of America 99(11), 7604-7609 (2002). 4.Hazra, S.,Rasheed, A.,Bhatwadekar, A., et al. Liver X receptor modulates diabetic retinopathy outcome in a mouse model of streptozotocin-induced diabetes. Diabetes 61(12), 3270-3279 (2012). 5.Joseph, S.B.,Castrillo, A.,Lafitte, B.A., et al. Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nature Medicine 9(2), 213-219 (2003). 6.Leik, C.E.,Carson, N.L.,Hennan, J.K., et al. GW3965, a synthetic liver X receptor (LXR) agonist, reduces angiotensin II-mediated pressor responses in Sprague-Dawley rats. British Journal of Pharmacology 151(4), 450-456 (2007). 7.Archer, A.,Stolarczyk, É.,Doria, M.L., et al. LXR activation by GW3965 alters fat tissue distribution and adipose tissue inflammation in ob/ob female mice. Journal of Lipid Research 54(5), 1300-1311 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 618.5 |
| 分子式 | C33H31ClF3NO3 • HCl |
| CAS号 | 405911-17-3 |
| 稳定性 | ≥ 2 years |
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