| 货号 | 10012642-250mg |
| 描述 | Nefazodone is an antagonist of monoamine transporters and receptors in the CNS (Kds = 26, 48, and 80 nM for 5-HT2A, α2-adrenergic, and D2 receptors, respectively).1,2,3 It has shown efficacy as an antidepressant, reducing anxiety and agitation symptoms, in clinical trials.4,3 |
| 别名 | BMY 13754;MJ13754-1; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Tatsumi, M.,Groshan, K.,Blakely, R.D., et al. Pharmacological profile of antidepressants and related compounds at human monoamine transporters. European Journal of Pharmacology 340(2-3), 249-258 (1997). 2.Cusack, B.,Nelson, A. and Richelson, E. Binding of antidepressants to human brain receptors: Focus on newer generation compounds. Psychopharmacology (Berl) 114(4), 559-565 (1994). 3.Owens, M.J.,Neal, W.,Plott, S.J., et al. Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J. Pharmacol. Exp. Ther. 283(3), 1305-1322 (1997). 4.Bauman, J.N.,Frederick, K.S.,Sawant, A., et al. Comparison of the bioactivation potential of the antidepressant and hepatotoxin nefazodone with aripiprazole, a structural analog and marketed drug. Drug Metabolism and Disposition 36(6), 1016-1029 (2008). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 22 |
| 纯度 | ≥98% |
| 计算分子量 | 470 |
| 分子式 | C25H32ClN5O2 • HCl |
| CAS号 | 82752-99-6 |
| 稳定性 | ≥ 2 years |
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