Wortmannin
货号：
10010591-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 10010591-1mg |
| 描述 | By phosphorylating phosphatidylinositol, phosphoinositide 3-kinases (PI3K), activates diverse cellular functions, including cell growth, differentiation, survival, and motility. Wortmannin is a potent, cell-permeable, and irreversible inhibitor of PI3K enzymes (IC50 = 1-10 nM). However, the class II PI3Ks from Drosophila, murine, and human differ in sensitivity to wortmannin (IC50 = 5, 50, 450 nM, respectively).1 Wortmannin also inhibits polo-like kinase 1 (IC50 = 24 nM)2 and polo-like kinase 3 (IC50 = 49 nM)3, as well as mTOR, DNA-PK, PI4K, MLCK, and p38 MAPK at 50 to 100 fold higher concentrations than that needed for PI3K inhibition. |
| 别名 | KY 12420; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Fruman, D.A.,Meyers, R.E. and Cantley, L.C. Phosphoinositide kinases. Annual Reviews of Biochemistry 67, 481-507 (2008).
2.Liu, Y.,Shreder, K.R.,Gai, W., et al. Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently inhibits mammalian polo-like kinase. Chemistry & Biology 12, 99-107 (2005).
3.Liu, Y.,Jiang, N.,Wu, J., et al. Polo-like kinases inhibited by wortmannin. Labeling site and downstream effects. The Journal of Biological Chemisty 282(4), 2505-2511 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 428.4 |
| 分子式 | C23H24O8 |
| CAS号 | 19545-26-7 |
| 稳定性 | ≥ 2 years |
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