| 货号 | 10010206-1mg |
| 描述 | Fatty acid binding protein 4 (FABP4) is a lipid transport protein that is also known as adipocyte FABP and aP2. In addition to adipocytes, it is also abundant in macrophages, along with FABP5, the epidermal FABP.1 BMS309403 is a cell-permeable, potent inhibitor of FABP4 that targets the fatty acid-binding pocket (Ki< 2 nM).2 It is less effective against FABP3 and FABP5 (Kis = 250 and 350 nM, respectively).2 BMS309403 is orally active, reducing atherosclerosis in mice lacking apoplipoprotein E.3,4 It also protects against the development of insulin resistance associated with genetic or diet-induced obesity in mice.3,5 FABP4 dose-dependently suppresses the release of MCP-1 from macrophages.1,5 |
| 别名 | Adipocyte FABP Inhibitor;A-FABP Inhibitor;ALBP Inhibitor;aP2 Inhibitor;FABP4 Inhibitor;Fatty Acid Binding Protein 4 Inhibitor; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Lan, H.,Cheng, C.C.,Kowalski, T.J., et al. Small-molecule inhibitors of FABP4/5 ameliorate dyslipidemia but not insulin resistance in mice with diet-induced obesity. Journal of Lipid Research 52(4), 646-656 (2011). 2.Sulsky, R.,Magnin, D.R.,Huang, Y., et al. Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP). Bioorganic & Medicinal Chemistry Letters 17(12), 3511-3515 (2007). 3.Furuhashi, M.,Tuncman, G.,Görgün, C.Z., et al. Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2. Nature 447, 959-965 (2007). 4.Lee, M.Y.,Li, H.,Xiao, Y., et al. Chronic administration of BMS309403 improves endothelial function in apolipoprotein E-deficient mice and in cultured human endothelial cells. British Journal of Pharmacology 162(7), 1564-1576 (2011). 5.Suhre, K.,Römisch-Margl, W.,de Angelis, M.H., et al. Identification of a potential biomarker for FABP4 inhibition: The power of lipidomics in preclinical drug testing. Journal of Biomolecular Screening 16(5), 467-475 (2011). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 474.6 |
| 分子式 | C31H26N2O3 |
| CAS号 | 300657-03-8 |
| 稳定性 | ≥ 2 years |
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