| 货号 | 10010089-1mg |
| 描述 | Inotilone is a cyclooxygenase (COX) inhibitor found in mushrooms of PhellinusandInonotus sps. that inhibits COX-2 over COX-1 with IC50 values of 0.03 and 0.36 µM, respectively.1,2 It is a poor inhibitor of hydroxysteroid dehydrogenase and xanthine oxidase (IC50s = 50.4 and 9.1 µM, respectively).1,2 Inotilone demonstrates anti-inflammatory, antiviral, and antioxidant effects in various experimental models.3,4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Wangun, H.V.K.,Härtl, A.,Kiet, T.T., et al. Inotilone and related phenylpropanoid polyketides from Inonotus sp. and their identification as potent COX and XO inhibitors. Organic & Biomolecular Chemistry 4, 2545-2548 (2006). 2.Shamshina, J.L., and Snowden, T.S. Convergent synthesis of potent COX-2 inhibitor inotilone. Tetrahedron Letters 48, 3767-3769 (2007). 3.Huang, G.-J.,Huang, S.-S., and Deng, J.-S. Anti-inflammatory activities of inotilone from Phellinus linteus through the inhibition of MMP-9, NF-kB, and MAPK activation in vitro and in vivo. PLoS One 7(5), e35922 (2012). 4.Hwang, B.S.,Lee, M.-S.,Lee, S.W., et al. Neuraminidase inhibitors from the fermentation broth of Phellinus linteus. Mycobiology 42(2), 189-192 (2014). 5.Lee, M.-S.,Hwang, B.S.,Lee, I.-K., et al. Chemical constituents of the culture broth of Phellinus linteus and their antioxidant activity. Mycobiology 43(1), 43-48 (2015). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 218.2 |
| 分子式 | C12H10O4 |
| CAS号 | 906366-79-8 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |