| 货号 | 10008672-50mg |
| 描述 | Celecoxib is an anti-inflammatory compound from the diaryl heterocycle class that selectively inhibits cyclooxygenase-2 (COX-2) (IC50s = 22.9 and 0.05 μM for COX-1 and COX-2, respectively).1,2 While it was initially hailed as a major therapeutic advance in treating inflammation while circumventing the gastrointestinal toxicity associated with traditional non-sterodial anti-inflammatory drugs, the use of celecoxib has been tempered due to its ability to induce adverse cardiovascular events.3 Celecoxib also displays chemopreventive activity in multiple tumor types via proapoptotic effects that are independent of its capacity to block COX-2.4,5,6 |
| 别名 | Celebra;Celebrex™;Onsenal;SC-58635;Xilebao;YM-177; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Uddin, J.M.,Rao, P.N.P., and Knaus, E.E. Design and synthesis of novel celecoxib analogues as selective cyclooxygenase-2 (COX-2) inhibitors: Replacement of the sulfonamide pharmacophore by a sulfonylazide bioisostere. Bioorg. Med. Chem. 11(23), 5273-5280 (2003). 2.Mardini, I.A., and Fitzgerald, G.A. Selective inhibitors of cyclooxygenase-2: A growing class of anti-inflammatory drugs. Molecular Interventions 1(1), 30-38 (2001). 3.Blobaum, A.L., and Marnett, L.J. Structural and functional basis of cyclooxygenase inhibition. Journal of Medicinal Chemistry 50(7), 1425-1441 (2007). 4.Jendrossek, V.,Handrick, R., and Belka, C. Celecoxib activates a novel mitochondrial apoptosis signaling pathway. The FASEB Journal 17, 1547-1549 (2003). 5.Leahy, K.M.,Ornberg, R.L.,Wang, Y., et al. Cyclooxygenase-2 inhibition by celecoxib reduces proliferation and induces apoptosis in angiogenic endothelial cells in vivo. Cancer Research 62, 625-631 (2002). 6.Zhu, J.,Huang, J.W.,Tseng, P.H., et al. From the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors. Cancer Research 64, 4309-4318 (2004). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 381.4 |
| 分子式 | C17H14F3N3O2S |
| CAS号 | 169590-42-5 |
| 稳定性 | ≥ 2 years |
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