| 货号 | 10008118-1mg |
| 描述 | Z-LLL-AMC is a fluorogenic substrate for the chymotrypsin-like activity of the 26S proteasome or 20S proteolytic core.1,2,3 Chymotrypsin-like activity can be quantified by fluorescent detection of free AMC (also known as 7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm. Z-LLL-AMC is typically used in cell lysates after experimental treatment.4 |
| 别名 | Z-Leu-Leu-Leu-AMC;Z-Leu-Leu-Leu-7-amido-4-Methylcoumarin;Proteasome Substrate I; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Tsubuki, S.,Saito, Y., and Kawashima, S. Purification and characterization of an endogenous inhibitor specific to the Z-Leu-Leu-Leu-MCA degrading activity in proteasome and its identification as heat-shock protein 90. FEBS Lett. 344(203), 229-233 (1994). 2.Tsubuki, S.,Kawasaki, H.,Saito, Y., et al. Purification and characterization of a Z-Leu-Leu-Leu-MCA degrading protease expected to regulate neurite formation: A novel catalytic activity in proteasome. Biochem. Biophys. Res. Commun. 196(3), 1995-1201 (1993). 3.Lynas, J.F.,Harriott, P.,Healy, A., et al. Inhibitors of the chymotrypsin-like activity of proteasome based on di- and tri-peptidyl α-keto aldehydes (glyoxals). Bioorg. Med. Chem. Lett 8(4), 373-378 (1998). 4.Figueiredo-Pereira, M.E.,Chen, W.E.,Li, J., et al. The antitumor drug aclacinomycin A, which inhibits the degradation of ubiquitinated proteins, shows selectivity for the chymotrypsin-like activity of the bovine pituitary 20 S proteasome. J. Biol. Chem. 271(28), 16455-16459 (1996). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 648.8 |
| 分子式 | C36H48N4O7 |
| CAS号 | 152015-61-7 |
| 稳定性 | ≥ 1 year |
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