| 货号 | 10008117-1mg |
| 描述 | Z-LLE-AMC is a fluorogenic substrate for the caspase-like post-glutamate peptide hydrolase of the 26S proteasome or 20S proteolytic core.1,2 Caspase-like activity can be quantified by fluorescent detection of free AMC (also known as 7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm. Z-LLE-AMC is typically used in cell lysates after experimental treatment.3,4 |
| 别名 | Z-Leu-Leu-Glu-AMC;Z-Leu-Leu-Glu-7-amido-4-Methylcoumarin;Proteasome Substrate II; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Orlowski, M.,Cardozo, C.,Hidalgo, M.C., et al. Regulation of the peptidylglutamyl-peptide hydrolyzing activity of the pituitary multicatalytic proteinase complex. Biochem. 30(24), 5999-6005 (1991). 2.Geier, E.,Pfeifer, G.,Wilm, M., et al. A giant protease with potential to substitute for some functions of the proteasome. Science 283(5404), 978-981 (1999). 3.Hamouda, M.-A.,Belhacene, N.,Puissant, A., et al. The small heat shock protein B8 (HSPB8) confers resistance to bortezomib by promoting autophagic removal of misfolded proteins in multiple myeloma cells. Oncotarget 5(15), 6252-6266 (2014). 4.Tadlock, L.,Yamagiwa, Y.,Hawker, J., et al. Transforming growth factor-β inhibition of proteasomal activity: A potential mechanism of growth arrest. Am. J. Physiol. Cell Physiol. 285(2), C277-C285 (2003). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 664.8 |
| 分子式 | C35H44N4O9 |
| CAS号 | 348086-66-8 |
| 稳定性 | ≥ 1 year |
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