| 货号 | 10007907-10mg |
| 描述 | D-erythro-Sphingosine is formed primarily from the breakdown of ceramide.1 Sphingosine inhibits protein kinase C and phosphatidic acid phosphohydrolase, whereas it activates phospholipase D and diacylglycerol (DAG) kinase.1 Phosphorylation of sphingosine by sphingosine kinases 1 and 2 (SPHK 1, SPHK 2) produces sphingosine-1-phosphate, a potent bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis.2,3,4 |
| 别名 | (−)-Sphingosine; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hannun, Y.A.,Luberto, C., and Argraves, K.M. Enzymes of sphingolipid metabolism: From modular to integrative signaling. Biochemistry 40(16), 4893-4903 (2001). 2.Takuwa, Y.,Takuwa, N., and Sugimoto, N. The Edg family G protein-coupled receptors for lysophospholipids: Their signaling properties and biological activities. Journal of Biochemistry 131, 767-771 (2002). 3.Ishii, I.,Fukushima, N.,Ye, X., et al. Lysophospholipid receptors: Signaling and biology. Annual Reviews of Biochemistry 73, 321-354 (2004). 4.Kluk, M.J., and Hla, T. Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors. Biochimica et Biophysica Acta 1582, 72-80 (2002). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 299.5 |
| 分子式 | C18H37NO2 |
| CAS号 | 123-78-4 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |