ML-348
货号：
18523-1mg 基本售价：
476.0 元 规格：
1 mg
产品信息
概述| 货号 | 18523-1mg |
| 描述 | Lysophospholipase 1 (LYPLA1) is a protein palmitoyl thioesterase responsible for depalmitoylation of the oncogene HRas.1,2 Palmitoylation of such oncogenes is thought to be required for trafficking and malignant transformation, making LYPLA1 a target for downregulating oncogenic signaling.1,2 ML-348 is a reversible LYPLA1 inhibitor with an IC50 value of 210 nM.3 It is 14-fold selective for LYPLA1 over LYPLA2 (IC50 = >3,000) and demonstrates little activity against a panel of more than 20 other serine hydrolases (IC50s = >10,000).3 |
| 别名 | CID 3238952;SID 160654487; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Martin, B.R. and Cravatt, B.F. Large-scale profiling of protein palmitoylation in mammalian cells. Nature Methods 6(2), 135-138 (2009).
2.Dekker, F.J.,Rocks, O.,Vartak, N., et al. Small-molecule inhibition of APT1 affects Ras localization and signaling. Nature Chemical Biology 6, 449-456 (2010).
3.Adibekian, A.,Martin, B.R.,Chang, J.W., et al. Characterization of a selective, reversible inhibitor of lysophospholipase 1 (LYPLA1). (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 415.8 |
| 分子式 | C18H17ClF3N3O3 |
| CAS号 | 899713-86-1 |
| 稳定性 | ≥ 2 years |
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