| 货号 | 18511-25g |
| 描述 | 4-Aminopyridine (4-AP) is a non-selective blocker of voltage-dependent K+-channels (Kv proteins in the KCN gene family). It has greatest potency at Kv1 (KCNA) and Kv3 (KCNC) family members (IC50s = 290, 590, 195, 13, 29, and 100 µM for subunits 1.1, 1.2, 1.3, 1.4, 3.1, and 3.2, respectively).1 4-AP also blocks Kv2 and Kv4 subunits at millimolar concentrations.1 When administered orally, 4-AP has benefits against multiple sclerosis, while injection into the brain produces epileptiform activity and can be used to study seizures.2,3,4 |
| 别名 | 4-AP;BRL 34915;Dalfampridine;Fampridine;NSC 15041; |
| 是否危险品 | 是 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Gutman, G.A.,Chandy, K.G.,Grissmer, S., et al. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacological Reviews 57(4), 473-508 (2005). 2.Blight, A.R.,Henney, H.R., III and Cohen, R. Development of dalfampridine, a novel pharmacologic approach for treating walking impairment in multiple sclerosis. Annals of the New York Academy of Sciences 1329, 33-44 (2014). 3.Jensen, H.B.,Ravnborg, M.,Dalgas, U., et al. 4-Aminopyridine for symptomatic treatment of multiple sclerosis: A systematic review. Ther.Adv.Neurol.Disord 7(2), 97-113 (2014). 4.Medina-Ceja, L.,Flores-Ponce, X.,Santerre, A., et al. Analysis of connexin expression during seizures induced by 4-aminopyridine in the rat hippocampus. Journal of Biomedical Science 22, (2015). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 94.1 |
| 分子式 | C5H6N2 |
| CAS号 | 504-24-5 |
| 稳定性 | ≥ 2 years |
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