| 货号 | 18463-1mg |
| 描述 | Lidocaine is an anesthetic that blocks voltage-gated Na+ channels (IC50 = 128 µM) with selectivity over L-type Ca2+ channels and GABAAreceptors.1 Lidocaine can also have pronociceptive effects by activating the transient receptor potential (TRP) channel TRPA1.2 N-(2,6-Dimethylphenyl)-2-(ethylmethylamino)acetamide is a lidocaine impurity.3,4 |
| 别名 | Lidocaine Impurity K;RAD240; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Lingamaneni, R. and Hemmings, H.C., Jr. Differential interaction of anaesthetics and antiepileptic drugs with neuronal Na+ channels, Ca2+ channels, and GABAA receptors. British Journal of Anaesthesia 90(2), 199-211 (2003). 2.Baraldi, P.G.,Preti, D.,Materazzi, S., et al. Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents. J. Med. Chem. 53(14), 5085-5107 (2010). 3.Hommerson, P.,Khan, A.M.,Bristow, T., et al. Drug impurity profiling by capillary electrophoresis/mass spectrometry using various ionization techniques. Rapid Communications in Mass Spectrometry 23(18), 2878-2884 (2009). 4.Prathyusha, P.,Shanmugasundaram, P. and Naidu, P.Y. Validated gradient stability-indicating UPLC method for the determination of lidocaine and its degradation impurities in pharmaceutical dosage form. IJAPA 3(1), 1-10 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 256.8 |
| 分子式 | C13H20N2O • HCl |
| CAS号 | 50295-20-0 |
| 稳定性 | ≥ 2 years |
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