Cdk4/6 Inhibitor IV
货号：
17974-1mg 基本售价：
476.0 元 规格：
1 mg
产品信息
概述| 货号 | 17974-1mg |
| 描述 | Cdk4/6 inhibitor IV is a cell-permeable triaminopyrimidine that reversibly blocks Cdk4/cyclin D1 and Cdk6/cyclin D1 activity with IC50 values of 1.5 and 5.6 μM, respectively.1 It demonstrates potent selectivity for Cdk4/6 over Cdk5/p35, v-abl, c-met, IGF-1R, insulin receptor, Cdk2/cyclin A, Cdk2/cyclin E, Cdk4/cyclin D2, Cdk6/cyclin D2, and Cdk1/cyclin B (IC50s = > 10-100 µM).1 At 5-10 µM, this compound blocks retinoblastoma protein phosphorylation at Ser780 and Ser795, inducing cell cycle arrest in the G1 phase and apoptosis in asynchronous cell lines.1 In mice bearing human HCT116 colon carcinoma xenografts, 30 mg/kg, i.p. Cdk/6 inhibitor IV suppressed tumor growth after 29 days of treatment.1 |
| 别名 | CINK4; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Soni, R.,OReilly, T.,Furet, P., et al. Selective in vivo and in vitro effects of a small molecule inhibitor of cyclin-dependent kinase 4. Journal of the National Cancer Institute 93(6), 436-446 (2001).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 456.6 |
| 分子式 | C27H32N6O |
| CAS号 | 359886-84-3 |
| 稳定性 | ≥ 2 years |
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