Topotecan (hydrochloride)
货号：
14129-10mg 基本售价：
476.0 元 规格：
10 mg
产品信息
概述| 货号 | 14129-10mg |
| 描述 | Topotecan is a water soluble analog of the alkaloid camptothecin that potently inhibits DNA topoisomerase I.1,2,3 It induces cytoxicity and DNA damage in human HT-29 colon adenocarcinoma cells with IC50 values of 33 nM and 0.28 μM, respectively.1 Topotecan demonstrates a broad spectrum of antitumor activity against a variety of other tumors including ovarian cancer, cervical cancer, neuroblastoma, brainstem glioma, and Ewing’s sarcoma.1,2 |
| 别名 | Hycamtin;NSC 609669;SKF 104864A; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Rothenberg, M.L. Topoisomerase I inhibitors: Review and update. Annals of Oncology 8(9), 837-855 (1997).
2.Dancey, J. and Eisenhauer, E.A. Current perspectives on camptothecins in cancer treatment. Br. J. Cancer 74(3), 327-338 (1996).
3.Schellens, J.H.M.,Creemers, G.J.,Beijnen, J.H., et al. Bioavailability and pharmacokinetics of oral topotecan: A new topoisomerase I inhibitor. British Journal of Cancer 73, 1268-1271 (1996).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 457.9 |
| 分子式 | C23H23N3O5 • HCl |
| CAS号 | 119413-54-6 |
| 稳定性 | ≥ 2 years |
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