CAY10603
货号：
13146-1mg 基本售价：
476.0 元 规格：
1 mg
产品信息
概述| 货号 | 13146-1mg |
| 描述 | Histone deacetylase 6 (HDAC6) is a class II HDAC that represses transcription by removing acetyl groups from histones. In addition, HDAC6 deacetylases tubulin, which is important in regulating microtubule stability and function. CAY10603 is a potent and selective inhibitor of HDAC6 (IC50 = 0.002 nM, as compared with 271, 252, 0.42, 6851, and 90.7 nM for HDAC1, 2, 3, 8, and 10, respectively).1 Also, CAY10603 prevents the growth of several pancreatic cancer cell lines (IC50 = 0.1-1 μM).1 The HDAC6 inhibitor is more active in inhibiting cell growth than the broad spectrum HDAC inhibitor suberoylanilide hydroxamic acid (SAHA). |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kozikowski, A.P.,Tapadar, S.,Luchini, D.N., et al. Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: A new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6. Journal of Medicinal Chemistry 51, 4370-4373 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 446.5 |
| 分子式 | C22H30N4O6 |
| CAS号 | 1045792-66-2 |
| 稳定性 | ≥ 2 years |
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