Penitrem A
货号：
11347-1mg 基本售价：
476.0 元 规格：
1 mg
产品信息
概述| 货号 | 11347-1mg |
| 描述 | Penitrem A is a tremorgenic fungal toxin that acts as an inhibitor of the large conductance calcium-activated potassium channel BKCa (SLO1, Maxi-K, KCa1.1), inhibiting the binding of charybdotoxin with an IC50 value of 1.7 μM.1 It is currently used to evaluate the role of BKCa-mediated potassium flux in various cell processes and responses.2,3 |
| 别名 | NSC 354845;Tremortin A; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Knaus, H.G.,McManus, O.B.,Lee, S.H., et al. Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels. Biochemistry 33(19), 5819-5828 (1994).
2.Asano, S.,Tune, J.D., and Dick, G.M. Bisphenol A activates Maxi-K (KCa1.1) channels in coronary smooth muscle. British Journal of Pharmacology 160, 160-170 (2010).
3.Moldes-Anaya, A.S.,Fonnum, F.,Eriksen, G.S., et al. In vitro neuropharmacological evaluation of penitrem-induced tremorgenic syndromes: Importance of the GABAergic system. Neurochemistry International 59, 1074-1081 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 634.2 |
| 分子式 | C37H44ClNO6 |
| CAS号 | 12627-35-9 |
| 稳定性 | ≥ 2 years |
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