| 货号 | 10010332-500ug |
| 描述 | The lipid messenger ceramide is converted to glucosylceramide by glucosylceramide synthase (GCS). In the reverse direction, non-lysosomal glucosylceramidase (GCase), also known as β-glucosidase 2 (BGD),1 cleaves the glucosyl moiety from glucosylceramide, liberating ceramide, which can be converted into sphingomyelin.2 AMP-deoxynojirimycin (AMP-dNM) is a hydrophobic derivative of dNM. It potently inhibits BGD (IC50 = 0.3 nM),3 less potently antagonizes GCS (IC50 = 25 nM),2 but only poorly inhibits other GCase isoforms. AMP-dNM has been shown to strongly suppress inflammation in a murine model of hapten-induced colitis,4 enhance insulin sensitivity in murine and rat models of insulin resistance,5 and induce sterol regulatory element-binding protein-regulated gene expression and cholesterol synthesis in HepG2 cells.1 |
| 别名 | Adamantane-pentyl-dNM;AMP-dNM;N-(5-adamantane-1-yl-methoxy-pentyl)-Deoxynojirimycin; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Bijl, N.,Scheij, S.,Houten, S., et al. The glucosylceramide synthase inhibitor N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin induces sterol regulatory element-binding protein-regulated gene expression and cholesterol synthesis in HepG2 cells. Journal of Pharmacology and Experimental Therapeutics 326(3), 849-855 (2008). 2.Aerts, J.M.,Hollak, C.,Boot, R., et al. Biochemistry of glycosphingolipid storage disorders: Implications for therapeutic intervention. Philosophical Transactions of the Royal Society of London.Series B, Biological Sciences 358, 905-914 (2003). 3.Overkleeft, H.S.,Renkema, G.H.,Neele, J., et al. Generation of specific deoxynojirimycin-type inhibitors of the non-lysosomal glucosylceramidase. The Journal of Biological Chemisty 273(41), 26522-26527 (1998). 4.Shen, C.,Bullens, D.,Kasran, A., et al. Inhibition of glycolipid biosynthesis by N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin protects against the inflammatory response in hapten-induced colitis. International Immunopharmacology 4, 939-951 (2004). 5.Aerts, J.M.,Ottenhoff, R.,Powlson, A.S., et al. Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity. Diabetes 56, 1341-1349 (2007). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 397.6 |
| 分子式 | C22H39NO5 |
| CAS号 | 216758-20-2 |
| 稳定性 | ≥ 1 year |
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