| 货号 | 10008385-500ug |
| 描述 | Prostaglandin D2(PGD2) is the major eicosanoid product of mast cells and is produced in large quantities by hematopoietic PGD synthase during allergic and asthmatic anaphylaxis.1 It causes vasodilation, flushing, hypotension, and is an inhibitor of platelet aggregation.1,2 Prostaglandin D2 methyl ester (PGD2 methyl ester) is a more lipid-soluble, cell-permeable prodrug form of PGD2.3 It binds to the human and mouse PGD2 receptors (DP1 and CRTH2/DP2) with 5-10 fold lower affinity than PGD2.4 |
| 别名 | PGD2 methyl ester; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Roberts, L.J., II, and Sweetman, B.J. Metabolic fate of endogenously synthesized prostaglandin D2 in a human female with mastocytosis. Prostaglandins 30, 383-400 (1985). 2.Giles, H., and Leff, P. The biology and pharmacology of PGD2. Prostaglandins 35, 277-300 (1988). 3.Suzuki, F.,Hayashi, H.,Ito, S., et al. Methyl ester of prostaglandin D2 as a delivery system of prostaglandin D2 into brain. Biochemica et Biophysica Acta 917, 224-230 (1987). 4.Hirai, H.,Abe, H.,Tanaka, K., et al. Gene structure and functional properties of mouse CRTH2, a prostaglandin D2 receptor. Biochemical and Biophysical Research Communications 307, 797-802 (2003). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥97% |
| 计算分子量 | 366.5 |
| 分子式 | C21H34O5 |
| CAS号 | 49852-81-5 |
| 稳定性 | ≥ 1 year |
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