N-Docosahexaenoyl Dopamine
货号：
9001394-1mg 基本售价：
462.0 元 规格：
1 mg
产品信息
概述| 货号 | 9001394-1mg |
| 描述 | N-Docosahexaenoyl dopamine (DHA-DA) is an amine conjugate of the neurotransmitter dopamine and the polyunsaturated fatty acid docosahexaenoic acid (DHA; Item No. 90310). DHA-DA is actively transported into the brain following intraperitoneal injections in mice, resulting in reduced general locomotor activity of 35-40% at a dose of 5 mg/kg.1 It is theorized that the DHA portion of the molecule serves as a carrier for DA through the blood-brain barrier via a DHA-mediated transport system.1 DHA-DA exhibits immune-modulating, anti-inflammatory activity in the range of 0.1-2.5 µM, suppressing the production of nitric oxide, IL-6, CCL20, MCP-1, and PGE2 (Item No. 14010) in LPS-stimulated macrophages and microglial cells without affecting NF-κB activity.2 |
| 别名 | DHA-DA;NMI 8739; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Shashoua, V.E. and Hesse, G.W. N-Docosahexaenoyl, 3-hydroxytyramine: A dopaminergic compound that penetrates the blood-brain barrier and suppresses appetite. Life Sciences 58(16), 1347-1357 (1996).
2.Wang, Y.,Plastina, P.,Vincken, J.-P., et al. N-docosahexaenoyl dopamine, an endocannabinoid-like conjugate of dopamine and the n-3 fatty acid docosahexaenoic acid, attenuates lipopolysaccharide-induced activation of microglia and macrophages via COX-2. ACS Chem. Neurosci. Epub ahead of print, (2016).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 463.7 |
| 分子式 | C30H41NO3 |
| CAS号 | 129024-87-9 |
| 稳定性 | ≥ 1 year |
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