| 货号 | 62175-5mg |
| 描述 | 2-Palmitoyl glycerol (2-PG) has been isolated along with the potent endocannabinoid 2-arachidonoyl glycerol (2-AG) from various tissues.1 Although 2-PG displays no intrinsic agonist activity on CB1 or CB2 receptors, it does potentiate the ability of 2-AG to inhibit adenylyl cyclase. 2-PG also potentiates the analgesic, hypokinetic, and anxiolytic effects of 2-AG in mice. This “entourage” effect has been attributed to the ability of compounds such as 2-PG to inhibit reuptake and/or compete with the active endocannabinoids for access to inactivating enzymes such as FAAH and monoglyceride lipase.2,3 Palmitoyl serinol is a stable analog of 2-PG bearing an amide linkage in place of the labile glyceryl ester. This has the potential to enhance its “entourage” activities as a result of a prolonged in vivo half-life. Palmitoyl serinol is also an analog of C-16 ceramide. Incubation of neuroblastoma cells with palmitoyl serinol causes apoptosis with an IC50 of approximately 80 µM.4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ben-Shabat, S.,Fride, E.,Sheskin, T., et al. An entourage effect: Inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity. European Journal of Pharmacology 353, 23-31 (1998). 2.Dinh, T.P.,Freund, T.F. and Piomelli, D. A role for monoglyceride lipase in 2-arachidonoylglycerol inactivation. Chemistry and Physics of Lipids 121, 149-158 (2002). 3.Fowler, C.J.,Jonsson, K.O. and Tiger, G. Fatty acid amide hydrolase: Biochemistry, pharmacology, and therapeutic possibilities for an enzyme hydrolyzing anandamide, 2-arachidonoylglycerol, palmitoylethanolamide, and oleamide. Biochemical Pharmacology 62, 517-526 (2001). 4.Bieberich, E.,Kawaguchi, T. and Yu, R.K. N-acylated serinol is a novel ceramide mimic inducing apoptosis in neuroblastoma cells. The Journal of Biological Chemisty 275, 177-181 (2000). 5.Bieberich, E.,Hu, B.,Silva, J., et al. Synthesis and characterization of novel ceramide analogs for induction of apoptosis in human cancer cells. Cancer Letters 181, 55-64 (2002). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 329.5 |
| 分子式 | C19H39NO3 |
| CAS号 | 126127-31-9 |
| 稳定性 | ≥ 1 year |
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