| 货号 | 19534-5mg |
| 描述 | Niguldipine is a dihydropyridine that acts as a potent, selective α1A-adrenoceptor antagonist (Ki = 0.16 nM).1,2,3 It less potently blocks L- and T-type Ca2+ channels (IC50s = 0.4 and 0.9 µM, respectively).4,5 |
| 别名 | B 844-39;NSC 617553; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Li, M.Y.,Tsai, K.C. and Xia, L. Pharmacophore identification of α1A-adrenoceptor antagonists. Bioorganic & Medicinal Chemistry Letters 15(3), 657-664 (2005). 2.Bylund, D.B. Subtypes of α1- and α2-adrenergic receptors. The FASEB Journal 6(3), 832-839 (1992). 3.van Rhee, A.M.,Jiang, J.L.,Melman, N., et al. Interaction of 1,4-dihydropyridine and pyridine derivatives with adenosine receptors: Selectivity for A3 receptors. Journal of Medicinal Chemistry 39(15), 2980-2989 (1996). 4.Klöckner, U. and Isenberg, G. The dihydropyridine niguldipine modulates calcium and potassium currents in vascular smooth muscle cells. British Journal of Pharmacology 97(3), 957-967 (1989). 5.Perez-Reyes, E.,Van Deusen, A.L. and Vitko, I. Molecular pharmacology of human Cav3.2 T-type Ca2+ channels: Block by antihypertensives, antiarrhythmics, and their analogs. Journal of Pharmacology and Experimental Therapeutics 328(2), 621-627 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 646.2 |
| 分子式 | C36H39N3O6 • HCl |
| CAS号 | 119934-51-9 |
| 稳定性 | ≥ 2 years |
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