Phloretin
货号：
14452-250mg 基本售价：
462.0 元 规格：
250 mg
产品信息
概述| 货号 | 14452-250mg |
| 描述 | Phloretin is a natural phenol which inhibits a variety of transporters. It inhibits the monocarboxylate transporters MCT1 and MCT2 (IC50 = 28 and 14 µM, respectively), restricting the rapid transport of monocarboxylates like lactate and pyruvate across the plasma membrane.1 Phloretin also blocks the sodium/D-glucose cotransporter (Ki = 86 µM) and the human concentrative nucleoside transporter 3 (Ki = 32 µM).2,3 |
| 别名 | NSC 407292;RJC 02792; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Bröer, S.,Bröer, A.,Schneider, H.P., et al. Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes. Biochemistry Journal 341, 529-535 (1999).
2.Wielert-Badt, S.,Lin, J.T.,Lorenz, M., et al. Probing the conformation of the sugar transport inhibitor phlorizin by 2D-NMR, molecular dynamics studies, and pharmacophore analysis. J.Med.Chem 43(9), 1692-1698 (2000).
3.Gupte, A. and Buolamwini, J.K. Synthesis and biological evaluation of phloridzin analogs as human concentrative nucleoside transporter 3 (hCNT3) inhibitors. Bioorganic & Medicinal Chemistry Letters 19(3), 917-921 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 274.3 |
| 分子式 | C15H14O5 |
| CAS号 | 60-82-2 |
| 稳定性 | ≥ 2 years |
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