| 货号 | 13986-5mg |
| 描述 | Fibrogenesis, as occurs in wound healing and fibrotic diseases, involves oxidative stress and inflammation followed by fibrosis.1,2 Pirfenidone is an orally active small molecule drug with antioxidant, anti-inflammatory, and antifibrotic effects.2 It has numerous cellular and in vivo effects, including the reduction of inflammatory cytokine production, suppression of TGF-β expression and TGF-mediated collagen I expression, and diminution of markers of oxidative stress.3,4 Pirfenidone has demonstrated effectiveness in both animal and human idiopathic pulmonary fibrosis.2,5,6 Moreover, it has use in other conditions with a significant fibrotic component, including tissue scarring, liver fibrosis, and diabetic nephropathy.4,7 |
| 别名 | AMR 69;Deskar;Pirespa; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Macías-Barragán, J.,Sandoval-Rodríguez, A.,Navarro-Partida, J., et al. The multifaceted role of pirfenidone and its novel targets. Fibrogenesis Tissue Repair 3(16), (2010). 2.Moeller, A.,Ask, K.,Warburton, D., et al. The bleomycin animal model: A useful tool to investigate treatment options for idiopathic pulmonary fibrosis? International Journal of Biochemistry and Cell Biology 40(3), 362-382 (2008). 3.Hisatomi, K.,Mukae, H.,Sakamoto, N., et al. Pirfenidone inhibits TGF-β1-induced over-expression of collagen type I and heat shock protein 47 in A549 cells. BMC Pulm.Med. 12(24), (2012). 4.Schaefer, C.J.,Ruhrmund, D.W.,Pan, L., et al. Antifibrotic activities of pirfenidone in animal models. Eur.Respir.Rev. 20(120), 85-97 (2011). 5.Adamali, H.I. and Maher, T.M. Current and novel drug therapies for idiopathic pulmonary fibrosis. Drug Des.Devel.Ther. 6, 261-272 (2012). 6.Noble, P.W.,Albera, C.,Bradford, W.Z., et al. Pirfenidone in patients with idiopathic pulmonary fibrosis (CAPACITY): Two randomised trials. Lancet 377, 1760-1769 (2011). 7.Seetohul, L.N.,Maskell, P.D.,De Paoli, G., et al. Deaths associated with new designer drug 5-IT. BMJ 345(e5625), (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 185.2 |
| 分子式 | C12H11NO |
| CAS号 | 53179-13-8 |
| 稳定性 | ≥ 2 years |
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