(-)-WIN 55,212-3 (mesylate)
货号：
12022-5mg 基本售价：
462.0 元 规格：
5 mg
产品信息
概述| 货号 | 12022-5mg |
| 描述 | (−)-WIN 55,212-3 is an aminoalkylindole derivative which acts as a competitive neutral antagonist of the human cannabinoid CB2 receptor, blocking both the stimulating action of CP 55,940 (pA2 = 6.1) and the inverse agonism of SR 144528 (Item No. 9000491) (pEC50 = 5.3).1 (−)-WIN 55,212-3 neither antagonizes nor mimics the effects of Δ9-THC on rat cerebellar membranes, which presumably express the CB1receptor.2,3 (−)-WIN 55,212-3 also weakly antagonizes the melatonin MT1 and muscarinic M4 receptors but has no effect on several other G protein-coupled receptors.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Savinainen, J.R.,Kokkola, T.,Salo, O.M.H., et al. Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB2 receptor. British Journal of Pharmacology 145, 636-645 (2005).
2.Pacheco, M.,Childers, S.R.,Arnold, R., et al. Aminoalkylindoles: Actions on specific G-protein-linked receptors. Journal of Pharmacology and Experimental Therapeutics 257(1), 170-183 (1991).
3.Compton, D.R.,Gold, L.H.,Ward, S.J., et al. Aminoalkylindole analogs: Cannabimimetic activity of a class of compounds structurally distinct from D 9-tetrahydrocannabinol. Journal of Pharmacology and Experimental Therapeutics 263(3), 1118-1126 (1992).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 522.6 |
| 分子式 | C27H26N2O3 • CH3SO3H |
| CAS号 | 131543-25-4 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
