(±)10(11)-EpDPA
货号：
10471-25ug 基本售价：
462.0 元 规格：
25 ug
产品信息
概述| 货号 | 10471-25ug |
| 描述 | Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers. (±)10(11)-EpDPA is a docosahexaenoic acid (DHA; Item No. 90310) epoxygenase metabolite, derived via epoxidation of the 10,11-double bond of DHA. It has been detected in rat brain and spinal cord, as well as human serum, and acts as a substrate for soluble epoxide hydrolase with a Km value of 5.1 µM.1,2 (±)10(11)-EpDPA and other epoxy metabolites of DHA are reported to demonstrate antihyperalgesic activity in inflammatory and neuropathic pain models and to potently inhibit angiogenesis and tumor growth in in vitroassays.1,3 |
| 别名 | (±)10,11-EDP;(±)10,11-EpDPE;(±)10,11-epoxy DPA;(±)10,11-epoxy Docosapentaenoic Acid; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Morisseau, C.,Inceoglu, B.,Schmelzer, K., et al. Naturally occurring monoepoxides of eicosapentaenoic acid and docosahexaenoic acid are bioactive antihyperalgesic lipids. Journal of Lipid Research 51, 3481-3490 (2010).
2.Lundström, S.L.,Yang, J.,Brannan, J.D., et al. Lipid mediator serum profiles in asthmatics significantly shift following dietary supplementation with omega-3 fatty acids. Mol.Nutr.Food Res. 57(8), 1378-1389 (2013).
3.Zhang, G.,Panigrahy, D.,Mahakian, L.M., et al. Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis. Proc. Natl. Acad. Sci. USA 110(16), 6530-6535 (2013).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 344.5 |
| 分子式 | C22H32O3 |
| CAS号 | 895127-65-8 |
| 稳定性 | ≥ 1 year |
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