| 货号 | 10465-25ug |
| 描述 | Docosahexaenoic acid (DHA, Item No. 90310) is the most abundant ω-3 fatty acid in neural tissues, especially in the brain and retina. (±)7(8)-EpDPA is an epoxide derivative of DHA that is generated by the action of cytochrome P450 epoxygenases.1 It is naturally occurring in plasma and brain and spinal cord tissues and is increased following dietary supplementation with ω-3 fatty acids.2,3 (±)7(8)-EpDPA and other epoxy metabolites of DHA modulate receptor and channel activities to evoke diverse effects, such as promoting vasodilation, inhibiting angiogenesis, and decreasing inflammatory and neuropathic pain.3,4,5,6 (±)7(8)-EpDPA is a substrate of soluble epoxide hydrolase (KM = 15 µM), which converts it to the corresponding diol.3 |
| 别名 | (±)7,8-EDP;(±)7,8-EpDPE;(±)7,8-epoxy DPA;(±)7,8-epoxy Docosapentaenoic Acid; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Spector, A.A., and Kim, H.Y. Cytochrome P450 epoxygenase pathway of polyunsaturated fatty acid metabolism. Biochimica et Biophysica Acta 1851(4), 356-365 (2015). 2.Fischer, R.,Konkel, A.,Mehling, H., et al. Dietary omega-3 fatty acids modulate the eicosanoid profile in man primarily via the CYP-epoxygenase pathway. Journal of Lipid Research 55(6), 1150-1164 (2014). 3.Morisseau, C.,Inceoglu, B.,Schmelzer, K., et al. Naturally occurring monoepoxides of eicosapentaenoic acid and docosahexaenoic acid are bioactive antihyperalgesic lipids. Journal of Lipid Research 51, 3481-3490 (2010). 4.Zhang, G.,Panigrahy, D.,Mahakian, L.M., et al. Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis. Proc. Natl. Acad. Sci. USA 110(16), 6530-6535 (2013). 5.Wang, R.,Chai, Q.,Lu, T., et al. Activation of vascular BK channels by docosahexaenoic acid is dependent on cytochrome P450 epoxygenase activity. Cardiovascular Research 90, 344-352 (2011). 6.Sato, K.,Chino, D.,Nishioka, N., et al. Pharmacological evidence showing significant roles for potassium channels and CYP epoxygenase metabolites in the relaxant effects of docosahexaenoic acid on the rat aorta contracted with U46619. Biological and Pharmaceutical Bullentin 37(3), 394-403 (2014). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 344.5 |
| 分子式 | C22H32O3 |
| CAS号 | 895127-66-9 |
| 稳定性 | ≥ 1 year |
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