| 货号 | 10007295-5mg |
| 描述 | Anandamide (AEA) is an endogenous cannabinoid that binds to both central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. The biological actions of AEA are terminated by cellular uptake and hydrolysis of the amide bond by the enzyme fatty acid amide hydrolase (FAAH). Arachidonoyl amide is an analog of anandamide (AEA) that lacks the hydroxyethyl moiety. It is hydrolyzed by FAAH more effectively than AEA but exhibits significantly weaker binding to the human CB1 receptor with a Ki of 9.6 µM.1,2 Arachidonoyl amide and AEA exhibit similar binding and translocation into cells via the AEA transporter. It inhibits [3H]-AEA uptake into human astrocytoma cells with an IC50 of 9 µM.3 Arachidonoyl amide also inhibits rat glial gap junction cell-cell communication by 90% at a concentration of 20 µM.4 |
| 别名 | Arachidonamide;Arachidonic Acid amide; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Felder, C.C.,Briley, E.M.,Axelrod, J., et al. Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction. Proceedings of the National Academy of Sciences of the United States of America 90, 7656-7660 (1993). 2.Lang, W.,Qin, C.,Lin, S., et al. Substrate specificity and stereoselectivity of rat brain microsomal anandamide amidohydrolase. Journal of Medicinal Chemistry 42, 896-902 (1999). 3.Piomelli, D.,Beltramo, M.,Glasnapp, S., et al. Structural determinants for recognition and translocation by the anandamide transporter. Proceedings of the National Academy of Sciences of the United States of America 96, 5802-5807 (1999). 4.Boger, D.L.,Sato, H.,Lerner, A.E., et al. Arachidonic acid amide inhibitors of gap junction cell-cell communication. Bioorganic & Medicinal Chemistry Letters 9, 1151-1154 (1999). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | >98% |
| 计算分子量 | 303.5 |
| 分子式 | C20H33NO |
| CAS号 | 85146-53-8 |
| 稳定性 | ≥ 1 year |
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