| 货号 | 15400-5mg |
| 描述 | Zerumbone is a natural monocyclic sesquiterpene first isolated from rhizomes of the wild ginger Z. zerumbet.1 It potently inhibits the activation of Epstein-Barr virus by phorbol esters (IC50 = 140 nM).1,2 Zerumbone inhibits Sonic hedgehog signaling and induces apoptosis in cancer cell lines.3,4,5 It has also been shown to have anti-oxidant and anti-inflammatory activities, contributing to immunomodulatory and hepatoprotective effects.6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Murakami, A.,Takahashi, M.,Jiwajinda, S., et al. Identification of zerumbone in Zingiber zerumbet smith as a potent inhibitor of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation. Bioscience, Biotechnology, and Biochemistry 63(10), 1811-1812 (1999). 2.Murakami, A.,Takahashi, D.,Kinoshita, T., et al. Zerumbone, a southeast asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: The α,β-unsaturated carbonyl group is a prerequisite. Carcinogenesis 23(5), 795-802 (2002). 3.Stanton, B.Z. and Peng, L.F. Small-molecule modulators of the Sonic Hedgehog signaling pathway. Molecular BioSystems 6(1), 44-54 (2010). 4.Sun, Y.,Sheng, Q.,Cheng, Y., et al. Zerumbone induces apoptosis in human renal cell carcinoma via Gli-1/Bcl-2 pathway. Pharmazie 68(2), 141-145 (2013). 5.Sehrawat, A.,Arlotti, J.A.,Murakami, A., et al. Zerumbone causes Bax- and Bak-mediated apoptosis in human breast cancer cells and inhibits orthotopic xenograft growth in vivo. Breast Cancer Research and Treatment 136(2), 429-441 (2012). 6.Rahman, H.S.,Rasedee, A.,How, C.W., et al. Zerumbone-loaded nanostructured lipid carriers: preparation, characterization, and antileukemic effect. Int.J.Nanomedicine 8, 2769-2781 (2013). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% |
| 计算分子量 | 218.3 |
| 分子式 | C15H22O |
| CAS号 | 471-05-6 |
| 稳定性 | ≥ 2 years |
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