LY171883
货号：
70710-5mg 基本售价：
448.0 元 规格：
5 mg
产品信息
概述| 货号 | 70710-5mg |
| 描述 | LY171883 is a selective, potent, orally active antagonist of the leukotriene D4receptor.1 Dissociation constants (KB) for LY171883 on guinea pig ileum and parenchyma are 0.07 and 0.34 µM, respectively.1 LY171883 is an inhibitor of phosphodiesterase obtained from human polymorphonuclear leukocytes (IC50 of 22.6 µM) and various guinea pig tissues (IC50s range from 6.9-209 µM).1 At a concentration of 50-100 µM, LY171883 binds to the PPARγ nuclear receptor, inducing adipogenesis in cultured NIH3T3 fibroblasts.2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Fleisch, J.H.,Rinkema, L.E.,Haisch, K.D., et al. LY171883, 1-[2-hydroxy-3-propyl-4-[4-(1H-tetrazol-5-yl)butoxy]phenyl]ethanone, an orally active leukotriene D4 antagonist. Journal of Pharmacology and Experimental Therapeutics 233, 148-157 (1985).
2.Sala, A.,Rossoni, G.,Buccellati, C., et al. Formation of sulphidopeptide-leukotrienes by cell-cell interaction causes coronary vasoconstriction in isolated, cell-perfused heart of rabbit. British Journal of Pharmacology 110, 1206-1212 (1993).
3.Tontonoz, P.,Hu, E., and Spiegelman, B.M. Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor. Cell 79, 1147-1156 (1994).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 22 |
| 纯度 | ≥98% |
| 计算分子量 | 318.4 |
| 分子式 | C16H22N4O3 |
| CAS号 | 88107-10-2 |
| 稳定性 | ≥ 2 years |
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