| 货号 | 18550-100ug |
| 描述 | Δ12-PGJ2 is a decomposition product of PGD2 in aqueous media in the presence of albumin.1 It has antitumor and antiviral activity, inhibiting growth of cultured L1210 cells at with an IC50 value of 0.7 µg/ml.2Δ12-PGJ2 is present in normal human urine with a 24 hour excretion rate of 50-150 ng.3 It is also a moderately potent PPARγ ligand.4 |
| 别名 | Δ12-PGJ2; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Fitzpatrick, F.A., and Wynalda, M.A. Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro. The Journal of Biological Chemisty 258, 11713-11718 (1983). 2.Kato, T.,Fukushima, M.,Kurozumi, S., et al. Antitumor activity of Δ7-prostaglandin A1 and Δ12-prostaglandin J2 in vitro and in vivo. Cancer Research 46, 3538-3542 (1986). 3.Hirata, Y.,Hayashi, H.,Ito, S., et al. Occurrence of 9-deoxy-Δ9,Δ12-13,14-dihydroprostaglandin D2 in human urine. The Journal of Biological Chemisty 263, 16619-16625 (1988). 4.Forman, B.M.,Tontonoz, P.,Chen, J., et al. 15-Deoxy-Δ12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ. Cell 83, 803-812 (1995). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥95% |
| 计算分子量 | 334.5 |
| 分子式 | C20H30O4 |
| CAS号 | 87893-54-7 |
| 稳定性 | ≥ 1 year |
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