Ulixertinib (hydrochloride)
货号：
18298-1mg 基本售价：
448.0 元 规格：
1 mg
产品信息
概述| 货号 | 18298-1mg |
| 描述 | Ulixertinib is a reversible ERK1/2 inhibitor that demonstrates an IC50 value of <0.3 nM for ERK2.1 In A375 melanoma cells with b-RafV600E mutation, it has been reported to reduce the levels of phosphorylated ERK2 and the downstream kinase RSK (IC50s = 4.1 and 0.14 μM, respectively).1 Ulixertinib has also been shown to inhibit A375 cell proliferation with an IC50 value of 180 nM.1 |
| 别名 | BVD-523;VRT-752271; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ward, R.A.,Colclough, N.,Challinor, M., et al. Structure-guided design of highly selective and potent covalent inhibitors of ERK1/2. Journal of Medicinal Chemistry 58(11), 4790-4801 (2015).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 469.8 |
| 分子式 | C21H22Cl2N4O2 • HCl |
| 稳定性 | ≥ 2 years |
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