PNU 74654
货号：
16349-1mg 基本售价：
448.0 元 规格：
1 mg
产品信息
概述| 货号 | 16349-1mg |
| 描述 | The Wnt signaling pathway is integral to normal biological processes and inappropriately active in many cancers.1 PNU 74654 binds to β-catenin (Kd = 450 nM), inhibiting its interaction with the transcription factor T cell factor 4 (Tcf4) resulting in disruption of the Wnt signaling pathway.2 Treatment of human adrenocortical cell lines with PNU 74654 significantly reduced expression of several Tcf/β-catenin target genes.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Barker, N. and Clevers, H. Mining the Wnt pathway for cancer therapeutics. Nature Reviews.Drug Discovery 5(12), 997-1014 (2006).
2.Trosset, J.Y.,Dalvit, C.,Knapp, S., et al. Inhibition of protein-protein interactions: The discovery of druglike β-catenin inhibitors by combining virtual and biophysical screening. Proteins 64(1), 60-67 (2006).
3.Durand, J.,Lampron, A.,Mazzuco, T.L., et al. Characterization of differential gene expression in adrenocortical tumors harboring β-catenin (CTNNB1) mutations. Journal of Clinical Endocrinology and Metabolism 96(7), E1206-E1211 (2011).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 320.3 |
| 分子式 | C19H16N2O3 |
| CAS号 | 113906-27-7 |
| 稳定性 | ≥ 2 years |
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