| 货号 | 15644-10mg |
| 描述 | Adenosine dialdehyde is an irreversible inhibitor of S-adenosylhomocysteine (SAH; Item Nos. 13603|9000372) hydrolase (IC50 = 40 nM), blocking the conversion of SAH to homocysteine and adenosine (Item No. 21232).1,2 This reduces the amount of homocysteine that can be converted to methionine and, subsequently, S-adenosylmethionine, a substrate of methyltransferases. In this way, adenosine dialdehyde indirectly inhibits cellular methyltransferase activity.3,4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Madhavan, G.V.,McGee, D.P.,Rydzewski, R.M., et al. Synthesis and antiviral evaluation of 6-substituted aristeromycins: Potential mechanism-based inhibitors of S-adenosylhomocysteine hydrolase. J. Med. Chem. 31(9), 1798-1804 (1988). 2.ODea, R.F.,Mirkin, B.L.,Hogenkamp, H.P., et al. Effect of adenosine analogues on protein carboxylmethyltransferase, S-adenosylhomocysteine hydrolase, and ribonucleotide reductase activity in murine neuroblastoma cells. Cancer Res. 47(14), 3656-3661 (1987). 3.Dung, T.T.M.,Yi, Y.-S.,Heo, J., et al. Critical role of protein L-isoaspartyl methyltransferase in basic fibroblast growth factor-mediated neuronal cell differentiation. BMB Rep. 49(8), 437-442 (2016). 4.Huang, H.-M.,Tam, M.F.,Tam, T.-C.S., et al. Proteomic analysis of stable protein methylation in lymphoblastoid cells. J. Biochem. 132(5), 813-818 (2002). 5.Miranda, T.B.,Cortez, C.C.,Yoo, C.B., et al. DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation. Mol. Cancer. Ther. 8(6), 1579-1588 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 265.2 |
| 分子式 | C10H11N5O4 |
| CAS号 | 34240-05-6 |
| 稳定性 | ≥ 2 years |
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