| 货号 | 14953-50mg |
| 描述 | Glutathione (GSH) serves as a nucleophilic co-substrate to glutathione transferase in the detoxification of xenobiotics and is an essential electron donor to glutathione peroxidases in the reduction of hydroperoxides.1,2,3 GSH ethyl ester is a cell permeable derivative of GSH that undergoes hydrolysis by intracellular esterases to release GSH.4 Effective transport of GSH ethyl ester has been used to protect cells against damage from radiation, oxidants, and various toxic compounds including heavy metals.5,6 |
| 别名 | GSH ethyl ester; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Jakoby, W.B. The glutathione S-transferases: A group of multifunctional detoxification proteins. Advances in Enzymology and Related Areas of Molecular Biology 46, 383-414 (1978). 2.Baillie, T.A. and Slatter, J.G. Glutathione: A vehicle for the transport of chemically reactive metabolites in vivo. Accounts of Chemical Research 24, 264-270 (1991). 3.Bedia, C. Glutathione: Metabolism and function. (1976). 4.Wellner, V.P.,Anderson, M.E.,Puri, R.N., et al. Radioprotection by glutathione ester: Transport of glutathione ester into human lymphoid cells and fibroblasts. Proceedings of the National Academy of Sciences of the United States of America 81(15), 4732-4735 (1984). 5.Zeevalk, G.D.,Manzino, L.,Sonsalla, P.K., et al. Characterization of intracellular elevation of glutathione (GSH) with glutathione monoethyl ester and GSH in brain and neuronal cultures: Relevance to Parkinson’s disease. Experimental Neurology 203(2), 512-520 (2007). 6.Kelly-Aubert, M.,Trudel, S.,Fritsch, J., et al. GSH monoethyl ester rescues mitochondrial defects in cystic fibrosis models. Human Molecular Genetics 20(14), 2745-2759 (2011). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 335.4 |
| 分子式 | C12H21N3O6S |
| CAS号 | 92614-59-0 |
| 稳定性 | ≥ 2 years |
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