| 货号 | 14574-25mg |
| 描述 | 4-DAMP is a potent antagonist of the muscarinic M3 receptor (pKi = 9.3).1,2,3 It is routinely used to study the regulation and functions of the M3receptor.4,5 4-DAMP also has a high affinity for the closely-related M5 receptor (pKi = 8.9).3 |
| 别名 | 4-Diphenylacetoxy-N-methyl-piperidine methiodide; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Barlow, R.B. and Shepherd, M.K. A search for selective antagonists at M2 muscarinic receptors. British Journal of Pharmacology 85(2), 427-435 (1985). 2.Barlow, R.B. and Kitchen, R. The actions of some esters of 4-hydroxyquinuclidine on guinea-pig ileum, artia and rat fundus strip. British Journal of Pharmacology 77(3), 549-557 (1982). 3.Watson, N.,Daniels, D.V.,Ford, A.P.D.W., et al. Comparative pharmacology of recombinant human M3 and M5 muscarinic receptors expressed in CHO-K1 cells. British Journal of Pharmacology 127(2), 590-596 (1999). 4.Joo, M.C.,Kim, Y.S.,Choi, E.S., et al. Changes in the muscarinic receptors on the colonic smooth muscles of rats with spinal cord injury. Ann.Rehabil.Med. 35(5), 589-598 (2011). 5.Lee, B.H.,Gauna, A.E.,Perez, G., et al. Autoantibodies against muscarinic type 3 receptor in Sjögrens syndrome inhibit aquaporin 5 trafficking. PLoS One 8(1), (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 22 |
| 纯度 | ≥98% |
| 计算分子量 | 451.3 |
| 分子式 | C21H26NO2 • I |
| CAS号 | 1952-15-4 |
| 稳定性 | ≥ 6 months |
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