PPADS (sodium salt)
货号：
14537-10mg 基本售价：
448.0 元 规格：
10 mg
产品信息
概述| 货号 | 14537-10mg |
| 描述 | P2X and P2Y purinergic receptors are ATP-sensitive receptors responsible for mediating a large variety of excitatory postsynaptic responses including fast transmission at central synapses, contraction of smooth muscle cells, platelet aggregation, macrophage activation, and apoptosis. PPADS is a non-selective P2 purinergic antagonist that blocks recombinant P2X1-5(IC50s = 1-2.6 μM), native P2Y2-like (IC50 = ~0.9 mM), and recombinant P2Y4(IC50 = ~15 mM) receptors.1 PPADS antagonism of ATP-sensitive P2 receptors produces neuroprotective effects in an ischemia model with permanent middle cerebral artery occlusion in spontaneously hypertensive rats.2 |
| 别名 | Pyridoxalphosphate-6-azophenyl-2,4-disulfonic acid; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lambrecht, G.,Friebe, T.,Grimm, U., et al. PPADS, a novel functionally selective antagonist of P2 purinoceptor-mediated responses. European Journal of Pharmacology 217, 217-219 (1992).
2.Lämmer, A.B.,Beck, A.,Grummich, B., et al. The P2 receptor antagonist PPADS supports recovery from experimental stroke in vivo. PLoS One 6(5), (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 599.3 |
| 分子式 | C14H10N3O12PS2 • 4Na |
| CAS号 | 192575-19-2 |
| 稳定性 | ≥ 6 months |
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