Amiloride (hydrochloride)
货号：
14409-1g 基本售价：
448.0 元 规格：
1 g
产品信息
概述| 货号 | 14409-1g |
| 描述 | Amiloride is a potassium-sparing diuretic that promotes the loss of sodium and water from the body by directly blocking sodium reabsorption through epithelial sodium channels.1 Amiloride can also block Na+/H+ exchangers in the heart, which can serve to minimize reperfusion injury in ischemic attacks.2 Additionally, acid-sensing ion channels, which are involved in nociceptor responses to pH, can also be inhibited by amiloride.3 |
| 别名 | MK-870; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lingueglia, E.,Voilley, N.,Lazdunski, M., et al. Physiological society symposium: Ion channels in health and disease. Molecular biology of the amiloride-sensitive epithelial Na+ channel. Experimental Physiology 81, 483-492 (1996).
2.Karmazyn, M. The myocardial sodium-hydrogen exchanger (NHE) and its role in mediating ischemic and reperfusion injury. Keio J.Med. 47(2), 65-72 (1998).
3.Qadri, Y.J.,Rooj, A.K. and Fuller, C.M. ENaCs and ASICs as therapeutic targets. American Journal of Physiology.Cell Physiology 302(7), C943-C965 (2012).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 266.1 |
| 分子式 | C6H8ClN7O • HCl |
| CAS号 | 2016-88-8 |
| 稳定性 | ≥ 2 years |
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