| 货号 | 13609-100ug |
| 描述 | Prostaglandin F2α(PGF2α) causes contraction of vascular, bronchial, intestinal, and myometrial smooth muscle, and also exhibits potent luteolytic activity.1,2 13,14-dihydro-16,16-difluoro PGF2α is an analog of PGF2α. While its biological activities have not been evaluated, it should be noted that the addition of two electron-withdrawing fluorine atoms has been used to stabilize prostanoids and significantly delay degradation in vivo.3 Importantly, 13,14-dihydro PGE1 has activity that is comparable to that of PGE1, suggesting that this analog of PGF2α could be biologically active.4,5 |
| 别名 | 13,14-dihydro-16,16-difluoro PGF2α; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Samuelsson, B.,Goldyne, M.,Granström, E., et al. Prostaglandins and thromboxanes. Annual Reviews of Biochemistry 47, 997-1029 (1978). 2.Basu, S. Novel cyclooxygenase-catalyzed bioactive prostaglandin F2α from physiology to new principles in inflammation. Medicinal Research Reviews 27(4), 435-468 (2007). 3.Hatano, Y.,Kohli, J.D.,Goldberg, L.I., et al. Vascular relaxing activity and stability studies of 10,10-difluoro-13,14-dehydroprostacyclin. Proceedings of the National Academy of Sciences of the United States of America 77(11), 6846-6850 (1980). 4.Änggård, E. The biological activities of three metabolites of prostaglandin E1. Acta Physiologica Scandinavica 66, 509-510 (1966). 5.Hamberg, M., and Samuelsson, B. On the metabolism of prostaglandins E1 and E2 in man. The Journal of Biological Chemisty 246, 6713-6721 (1971). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 392.5 |
| 分子式 | C20H34F2O5 |
| 稳定性 | ≥ 1 year |
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