| 货号 | 11636-500mg |
| 描述 | Amphotericin B is a classic antifungal polyene macrolide that has been used in the treatment of systemic fungal infections, primarily caused by C. albicans,A. fumigatus, and parasitic L. protozoans, as well as in tissue culture to prevent fungi from contaminating cell cultures.1,2,3 Amphotericin B binds with ergosterol, the main component of fungal cell membranes, forming a transmembrane channel that results in altered plasma membrane permeability and leakage of vital cytoplasmic components, such as K+, ultimately inducing cell death.4 Because prolonged use of amphotericin B is associated with infusion-related events and nephrotoxicity, lipid-based formulations have been devised for more favorable clinical relevance.1,2 |
| 别名 | Abelcet®;AmBisome®;Amphocin®;Ampho-Moronal®;Amphozone®;Fungilin®;Fungizone®;Halizon®;LNS-AmB;NSC 527017; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Miceli, M.H., and Chandrasekar, P. Safety and efficacy of liposomal amphotericinB for the empirical therapy of invasive fungalinfections in immunocompromised patients. Infection and Drug Resistance 5, 9-16 (2012). 2.Wasan, K.M.,Wasan, E.K.,Gershkovich, P., et al. Highly effective oral amphotericin B formulation against murine visceral leishmaniasis. Journal of Infectious Diseases 200, 357-360 (2009). 3.Radomski, N.,Cambau, E.,Moulin, L., et al. Comparison of culture methods for isolation of nontuberculous mycobacteria from surface waters. Applied and Environmental Microbiology 76(11), 3514-3520 (2010). 4.Ogita, A.,Fujita, K.i., and Tanaka, T. Enhancing effects on vacuole-targeting fungicidal activity of amphotericin B. Front.Microbiol. 3(100), 1-6 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 924.1 |
| 分子式 | C47H73NO17 |
| CAS号 | 1397-89-3 |
| 稳定性 | ≥ 2 years |
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