| 货号 | 10009222-5mg |
| 描述 | Sphingosine kinase isoforms, SPHK 1 and SPHK 2 , catalyze the phosphorylation of sphingosine to sphingosine-1-phosphate (S1P). S1P exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis.1,2,3 SPHK I2 is a potent, selective inhibitor of SPHK 1 with anti-proliferative activity.4 It exhibits non-ATP-competitive inhibition of human recombinant GST-SPHK 1 with an IC50 value of 0.5 µM, with no inhibition against ERK2, PI3-kinase, or PKCα at concentrations up to 60 µM. SPHK I2 inhibits proliferation of several human cancer cell lines (T-24, MCF-7, NCI/ADR, and MCF-7/VP) with IC50 values in the low µM range (0.9-4.6 µM).4 |
| 别名 | SKI II;SPHK I2; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Takuwa, Y.,Takuwa, N., and Sugimoto, N. The Edg family G protein-coupled receptors for lysophospholipids: Their signaling properties and biological activities. Journal of Biochemistry 131, 767-771 (2002). 2.Ishii, I.,Fukushima, N.,Ye, X., et al. Lysophospholipid receptors: Signaling and biology. Annual Reviews of Biochemistry 73, 321-354 (2004). 3.Kluk, M.J., and Hla, T. Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors. Biochimica et Biophysica Acta 1582, 72-80 (2002). 4.French, K.J.,Schrecengost, R.S.,Lee, B.D., et al. Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Research 63, 5962-5969 (2003). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 302.8 |
| 分子式 | C15H11ClN2OS |
| CAS号 | 312636-16-1 |
| 稳定性 | ≥ 2 years |
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