| 货号 | 16554-1mg |
| 描述 | Ferutinin is a plant-derived ester of a sesquiterpenic alcohol that acts as an agonist for estrogen receptor (ER) α (IC50 = 33.1 nM) and an agonist/antagonist for ERβ (IC50 = 180.5 nM).1 It also demonstrates ionophoretic properties, increasing calcium permeability of lipid bilayer membranes, mitochondria, thymocytes, sarcoplasmic reticulum, and liposomes at a concentration range of 1-50 µM.2,3,4 Ferutinin is cytotoxic to MCF-7 breast and TCC bladder cancer cells as well as human foreskin HFF3 fibroblasts (IC50s = 29, 24, and 36 µg/ml in vitro after 72 hours of exposure).3 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ikeda, K.,Arao, Y.,Otsuka, H., et al. Terpenoids found in the Umbelliferae family act as agonists/antagonists for ERα and ERβ: Differential transcription activity between ferutinine-liganded ERα and ERβ. Biochemical and Biophysical Research Communications 291(2), 354-360 (2002). 2.Abramov, A.Y.,Zamaraeva, M.V.,Hagelgans, A.I., et al. Influence of plant terpenoids on the permeability of mitochondria and lipid bilayers. Biochimica et Biophysica Acta 1512(1), 98-110 (2001). 3.Matin, M.M.,Nakhaeizadeh, H.,Bahrami, A.R., et al. Ferutinin, an apoptosis inducing terpenoid from Ferula ovina. Asian Pac.J.Cancer Prev. 15(5), 2123-2128 (2014). 4.Zamaraeva, M.V.,Charishnikova, O.,Saidkhodjaev, A., et al. Calcium mobilization by the plant estrogen ferutinin does not induce blood platelet aggregation. Pharmacological Reports 62(6), 1117-1126 (2010). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | 4 |
| 纯度 | ≥98% |
| 计算分子量 | 358.5 |
| 分子式 | C22H30O4 |
| CAS号 | 41743-44-6 |
| 稳定性 | ≥ 2 years |
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