AdipoRon
货号：
15941-5mg 基本售价：
435.0 元 规格：
5 mg
产品信息
概述| 货号 | 15941-5mg |
| 描述 | Adiponectin expressed by adipocytes exerts antidiabetic effects by binding to adiponectin receptor (AdipoR)1, which activates AMPK pathways, and AdipoR2, which activates PPARα pathways. AdipoRon is an orally active small molecule AdipoR agonist that binds AdipoR1 and AdipoR2 with KD values of 1.8 and 3.1 µM, respectively.1 At 50 mg/kg, it acts similarly to adiponectin, activating AMPK and PPARα pathways and reducing insulin resistance and glucose intolerance in wild type mice fed a high-fat diet and in genetically obese db/dbmice.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Okada-Iwabu, M.,Yamauchi, T.,Iwabu, M., et al. A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature 503(7477), 493-499 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 428.5 |
| 分子式 | C27H28N2O3 |
| CAS号 | 924416-43-3 |
| 稳定性 | ≥ 2 years |
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