Ro 3306
货号：
15149-1mg 基本售价：
435.0 元 规格：
1 mg
产品信息
概述| 货号 | 15149-1mg |
| 描述 | Cyclin-dependent kinase 1 (Cdk1) complexes with different cyclins, with the cyclin determining substrate specificity. Ro 3306 is a cell-permeable, reversible inhibitor of Cdk1, showing preference for Cdk1/cyclin B1(Ki = 35 nM) over Cdk1/cyclin A (Ki = 110 nM), two CDK complexes which regulate cell cycling.1 It also inhibits Cdk2 (Ki = 340 nM), PKCδ (Ki = 318 nM), and serum- and glucocorticoid-induce kinase (Ki = 497 nM) but not Cdk4.1 Through its effects on Cdk1, Ro 3306 reversibly arrests proliferating cells at the G2/M phase border, allowing cell synchronization without the use of microtubule poisons.2 Prolonged treatment of cells with Ro 3306 induces apoptosis and this can be augmented in acute myeloid leukemia cells by stimulating p53 activity with nutlin-3.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Vassilev, L.T.,Tovar, C.,Chen, S., et al. Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1. Proceedings of the National Academy of Sciences of the United States of America 103(28), 10660-10665 (2006).
2.Vassilev, L.T. Cell cycle synchronization at the G2/M phase border by reversible inhibition of CDK1. Cell Cycle 5(22), 2555-2556 (2006).
3.Kojima, K.,Shimanuki, M.,Shikami, M., et al. Cyclin-dependent kinase 1 inhibitor RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis in AML. Cancer Science 100(6), 1128-1136 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 351.4 |
| 分子式 | C18H13N3OS2 |
| CAS号 | 872573-93-8 |
| 稳定性 | ≥ 2 years |
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