| 货号 | 13689-1mg |
| 描述 | Peroxisome proliferator-activated receptor (PPAR) γ is a nuclear receptor that, when activated, regulates fatty acid storage and glucose metabolism.1 The best known class of PPARγ ligands are the thiazolidinediones, including troglitazone (Item No. 71750) and rosiglitazone (Item No. 71740).2 GW 1929 is a non-thiazolidinedione activator of PPARγ that binds with a Ki value of 1.4 nM, with greater than 1,000-fold selectivity over other PPAR subtypes.3 It has anti-hyperglycemic and anti-hyperlipidemic activity when given orally in mouse and rat models of type 2 diabetes.3,4Bothin vitroandin vivo effects of GW 1929 on PPARγ greatly exceed those produced by troglitazone.3,4 In addition, GW 1929 has neuroprotective effects in global cerebral ischemic-reperfusion injury that are related to reduced inflammation and apoptotic DNA fragmentation.5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Yang, Q. and Li, Y. Roles of PPARs on regulating myocardial energy and lipid homeostasis. Journal of Molecular Biology 85, 697-706 (2007). 2.Lehmann, J.M.,Moore, L.B.,Smith-Oliver, T.A., et al. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ). The Journal of Biological Chemisty 270, 12953-12956 (1995). 3.Henke, B.R.,Blanchard, S.G.,Brackeen, M.F., et al. N-(2-Benzoylphenyl)-L-tyrosine PPARγ agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents. Journal of Medicinal Chemistry 41(25), 5020-5036 (1998). 4.Brown, K.K.,Henke, B.R.,Blanchard, S.G., et al. A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-γ reverses the diabetic phenotype of the Zucker diabetic fatty rat. Diabetes 48(7), 1415-1424 (1999). 5.Kaundal, R.K. and Sharma, S.S. GW1929: A nonthiazolidinedione PPARγ agonist, ameliorates neurological damage in global cerebral ischemic-reperfusion injury through reduction in inflammation and DNA fragmentation. Behavioural Brain Research 216(2), 606-612 (2011). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 495.6 |
| 分子式 | C30H29N3O4 |
| CAS号 | 196808-24-9 |
| 稳定性 | ≥ 2 years |
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