| 货号 | 11039-1mg |
| 描述 | Geldanamycin (Item No. 13355) is a potent inhibitor of Hsp90 that exhibits severe hepatotoxicity when used in vivo.1 17-AAG is an analog of geldanamycin which has potent in vivo activity and reduced toxicity.1,2,3 Like other Hsp90 inhibitors, 17-AAG has diverse anti-tumor actions and has potential in treating certain types of cancer.1,2,3 17-AAG inhibits the growth of prostate cancer cell lines (IC50 = 25-45 nM).4 17-AAG promotes the degradation of HER2 and induces growth arrest and apoptosis in breast cancer cells overexpressing HER2 (IC50 = 4-72 nM).5 |
| 别名 | BMS 722782;CP 127374;KOS 953;NSC 330507;Tanespimycin; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Taldone, T.,Sun, W. and Chiosis, G. Discovery and development of heat shock protein 90 inhibitors. Bioorganic & Medicinal Chemistry 17(6), 2225-2235 (2009). 2.Pacey, S.,Gore, M.,Chao, D., et al. A phase II trial of 17-allylamino, 17-demethoxygeldanamycin (17-AAG, tanespimycin) in patients with metastatic melanoma. Investigational New Drugs 30, 341-349 (2012). 3.Ramanathan, R.K.,Trump, D.L.,Eiseman, J.L., et al. Phase I pharmacokinetic-pharmacodynamic study of 17-(allylamino)-17-demethoxygeldanamycin (17AAG, NSC 330507), a novel inhibitor of heat shock protein 90, in patients with refractory advanced cancers. Clinical Cancer Research 11(9), 3385-3391 (2005). 4.Solit, D.B.,Zheng, F.F.,Drobnjak, M., et al. 17-allylamino-17-demethoxygeldanamycin induces the degradation of androgen receptor and HER-2/neu and inhibits the growth of prostate cancer xenografts. Clinical Cancer Research 8, 986-993 (2002). 5.Münster, P.N.,Marchion, D.C.,Basso, A.D., et al. Degredation of HER2 by ansamycins induces growth arrest and apoptosis in cells with HER2 overexpression via a HER3, phosphatidylinositol 3-kinase-AKT-dependent pathway. Cancer Research 62, 3132-3137 (2002). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 585.7 |
| 分子式 | C31H43N3O8 |
| CAS号 | 75747-14-7 |
| 稳定性 | ≥ 2 years |
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