| 货号 | 21457-1mg |
| 描述 | NGB 2904 is an antagonist that is selective for the dopamine D3 receptor (Ki = 1.4 nM).1 It potently inhibits quinpirole-stimulated mitogenesis (IC50 = 6.8 nM).2 NGB 2904 attenuates cocaine- and stress-induced reinstatement of drug-seeking behavior in rats.3,4 It also increases spontaneous and amphetamine-stimulated locomotion in mice.5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Yuan, J.,Chen, X.,Brodbeck, R., et al. NGB 2904 and NGB 2849: Two highly selective dopamine D3 receptor antagonists. Bioorg. Med. Chem. Lett. 8(19), 2715-2718 (1998). 2.Grundt, P.,Carlson, E.E.,Cao, J., et al. Novel heterocyclic trans olefin analogues of N-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl}arylcarboxamides as selective probes with high affinity for the dopamine D3 receptor. J. Med. Chem. 48(3), 839-848 (2005). 3.Gilbert, J.G.,Newman, A.H.,Gardner, E.L., et al. Acute administration of SB-277011A, NGB 2904, or BP 897 inhibits cocaine cue-induced reinstatement of drug-seeking behavior in rats: Role of dopamine D3 receptors. Synapse 57(1), 17-28 (2005). 4.Xi, Z.-X.,Newman, A.H.,Gilbert, J.G., et al. The novel dopamine D3 receptor antagonist NGB 2904 inhibits cocaine’s rewarding effects and cocaine-induced reinstatement of drug-seeking behavior in rats. Neuropsychopharmacology 31(7), 1393-1405 (2006). 5.Pritchard, L.M.,Newman, A.H.,McNamara, R.K., et al. The dopamine D3 receptor antagonist NGB 2904 increases spontaneous and amphetamine-stimulated locomotion. Pharmacol. Biochem. Behav. 86(4), 718-726 (2007). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 530.9 |
| 分子式 | C28H29Cl2N3O • HCl |
| CAS号 | 189061-11-8 |
| 稳定性 | ≥ 2 years |
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