| 货号 | 19058-10mg |
| 描述 | Methsuximide is a succinimide that is converted to N-desmethylmethosuximide, a channel blocker that targets low threshold calcium currents.1,2 Methsuximide is a substrate of cytochrome P450 (CYP) isoform 2C19 that, in turn, inhibits CYP2C19-mediated metabolism of biguanides.3 Methsuximide has been shown to have anticonvulsant properties in clinical trials.4,5 |
| 别名 | (±)-Mesuximide;PM 396; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Coulter, D.A. Antiepileptic drug cellular mechanisms of action: where does lamotrigine fit in? J.Child.Neurol. 12(Suppl 1), (1997). 2.Nicholls, P.J., and Orton, T.C. The physiological disposition of 14C-methsuximide in the rat. Br.J.Pharmacol. 45(1), 48-59 (1972). 3.Wright, J.D.,Helsby, N.A., and Ward, S.A. The role of S-mephenytoin hydroxylase (CYP2C19) in the metabolism of the antimalarial biguanides. British Journal of Clinical Pharmacology 39(4), 441-444 (1995). 4.Schmidt, D., and Bourgeois, B. A risk-benefit assessment of therapies for Lennox-Gastaut syndrome. Drug Safety 22(6), 467-477 (2000). 5.Sigler, M.,Strassburg, H.M., and Boenigk, H.E. Effective and safe but forgotten: methsuximide in intractable epilepsies in childhood. Seizure 10(2), 120-124 (2001). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 203.2 |
| 分子式 | C12H13NO2 |
| CAS号 | 77-41-8 |
| 稳定性 | ≥ 2 years |
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