CP 640,186
货号：
17691-1mg 基本售价：
434.0 元 规格：
1 mg
产品信息
概述| 货号 | 17691-1mg |
| 描述 | Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism that enables the synthesis of malonyl-CoA, a precursor for fatty acids. CP 640,186 is an isozyme-nonselective ACC inhibitor with IC50 values of 53 and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2, respectively.1 It has been shown to lower malonyl-CoA levels and to inhibit hepatic fatty acid and triglyceride synthesis both in vitroandin vivo.1 CP 640,186 can also stimulate muscle fatty acid oxidation (EC50 = 1.3 µM in rat epitrochlearis muscle strips) and lower whole body respiratory quotient in rats (ED50 = ~30 mg/kg).1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Harwood, H.J., Jr.,Petras, S.F.,Shelly, L.D., et al. Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals. The Journal of Biological Chemisty 278(39), 37099-37111 (2016).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 485.6 |
| 分子式 | C30H35N3O3 |
| CAS号 | 591778-68-6 |
| 稳定性 | ≥ 2 years |
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